Correlation among NYHA cardiac function class,LVEF and NT-proBNP level
10.3969/j.issn.1008-0074.2015.06.09
- VernacularTitle:NT-proBNP 水平与心功能分级及 LVEF 值的相关性
- Author:
Maohai LIN
;
Kaijian HUANG
;
Shouxue LIN
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain;
Ventricular function;
Heart failure
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(6):617-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlation among NYHA cardiac function class ,left ventricular ejection fraction (LVEF) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and relationship between NT‐proBNP and inci‐dence rate of major adverse cardiovascular events (MACE) .Methods :A total of 243 patients with different degree cardiac function were selected ,including 40 cases with normal cardiac function ,46 cases with NYHA cardiac func‐tion class I ,57 cases with NYHA cardiac function class Ⅱ ,58 cases with NYHA cardiac function class Ⅲ and 42 ca‐ses with NYHA cardiac function class Ⅳ . Plasma NT‐proBNP level and LVEF were measured and correlations a‐mong NYHA cardiac function class ,LVEF and NT‐proBNP were analyzed ;all subjects were followed up for 24 months to observe the relationship between plasma NT‐proBNP level and incidence rate of MACE .Results:Plasma NT‐proBNP level and incidence rate of MACE significantly rose along with NYHA cardiac function class increased , P=0.001 both ;Spearman correlation analysis indicated that NT‐proBNP level was positively correlated with NYHA cardiac function class (r=0.856 , P<0.01) and inversely correlated with LVEF (r= -0.601 , P<0.01);along with NT‐proBNP level rose (0~4th class) ,incidence rate of MACE significantly increased (namely 20% ,41. 3% , 50.9% ,63.8% and 71.4% respectively , P=0.001) .Conclusion:NT‐proBNP level is significantly correlated with NYHA cardiac function class and LVEF ,and related with MACE incidence rate ,which possesses important diagnos‐tic and prognostic value .