Comparison of therapeutic effect between rosuvastatin and atorvastatin on levels of lipoprotein and in-flammatory factors in patients with acute coronary syndrome
10.3969/j.issn.1008-0074.2015.06.14
- VernacularTitle:瑞舒伐他汀与阿托伐他汀对急性冠脉综合征患者血脂与CRP 疗效的比较
- Author:
Yunxia MAO
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Rosuvastatin;
Atorvastatin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(6):633-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore therapeutic effect of rosuvastatin and atorvastatin treatment on levels of lipoprotein and inflammatory factors in patients with acute coronary syndrome (ACS) .Methods :A total of 74 ACS patients , who were treated in our department of cardiology from Mar 2008 to Feb 2014 ,were selected .According to random number table ,they were randomly and equally divided into rosuvastatin group and atorvastatin group .Therapeutic effect on 24d after administration ,levels of low density lipoprotein cholesterol (LDL‐C) ,high density lipoprotein cholesterol (HDL‐C) ,interleukin (IL)‐18 and C reactive protein (CRP) before and four weeks after treatment were compared between two groups .Results:On 24d after treatment ,total effective rat of rosuvastatin group was significantly higher than that of atorvastatin group (83.8% vs .75.7% , P< 0.05);after four‐week treatment , compared with atorvastatin group ,there were significant reductions in levels of LDL‐C [ (1. 8 ± 0. 2 ) mmol/L vs . (1.4 ± 0.1) mmol/L] ,IL‐18 [ (1.8 ± 0.2) vs .(1.4 ± 0.1)] and CRP [ (1.9 ± 0.3) pg/ml vs .(1.4 ± 0.2) pg/ml],andsignificantriseinHDL‐Clevel[(1.4±0.2)mmol/Lvs.(1.9±0.3)mmol/L]inrosuvastatingroup,P<0.05 all .Conclusion:Rosuvastatin therapy can achieve better adjusting lipid and anti‐inflammation effect than those of atorvastatin in patients with acute coronary syndrome ,which is worth clinical extending .
