Association between polymorphism of TGF-β1 gene and type 2 diabetes mellitus in Chinese Han population in Shanghai
10.3969/j.issn.1006-5725.2015.18.046
- VernacularTitle:转化生长因子－β1基因多态性与上海汉族人群2型糖尿病的相关性
- Author:
Junyan LI
;
Feng TAO
;
Xinxing WU
;
Yingzi TAN
;
Lin HE
;
Hao LU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Polymorphism;
TGF-β1
- From:
The Journal of Practical Medicine
2015;(18):3078-3080
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association between transforming growth factor-β1 (TGF-β1) polymorphism and type 2 diabetes mellitus in Han population of Shanghai. Methods In this case-control study , 1 234 cases of T2DM patients were recruited and 1 272 healthy individuals were selected as control. Five ml of blood sample was collected from each subject ,from which the whole genomic DNA was extracted.The polymorphism was detected by the Taqman technology. Result Significant association was observed in TGF-β1 T896C genotypes and alleles with T2DM (P = 0.0001 and P = 0.004, OR = 1.18 [1.05 ~ 1.33], respectively). Conclusion The polymorphism of T896C in TGF-β1 gene may be associated with T2DM in Han population from Shanghai.
