The effects of Gegen Qinlian decoction on high sensitive C-reactive protein and interleukin-6 in serum of the rats with periodontitis
10.3969/j.issn.1001-3733.2015.06.009
- VernacularTitle:葛根芩连汤对牙周炎大鼠血清 hs-CRP、IL-6表达的影响
- Author:
Xin LUO
;
Dan WANG
;
Wei PENG
;
Xiaojie FENG
- Publication Type:Journal Article
- Keywords:
Gegen Qinlian decoction;
Periodontitis;
High sensitive C-reactive protein(hs-CRP);
Interleukin-6 (IL-6)
- From:
Journal of Practical Stomatology
2015;(6):780-783
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of Gegen Qinlian decoction on high sensitive C-reactive protein(hs-CRP)and interleu-kin-6(IL-6)in serum of the rats with periodontitis and the IL-6 expression level in periodontal tissues.Methods:45 Wistar rats were randomly divided into 2 groups:control group N(n =1 0),periodontitis model group P(n =35).After periodontitis model was identi-fied by the examination of 5 rats,the rest rats were randomly divided into 3 groups(n =1 0)and treated by gavage of saline(group P0 ), metronidazole(group P1 )and Gegen Qinlian decoction(group P2 )respectively for 4 weeks.Then all the rats were sacrificed.Serum was immediately harvested for the test of serum hs-CRP and IL-6 levels by ELISA.Attachment loss level(AL)was examined by pa-thology.IL-6 expression in periodontal tissues was examined by S-P immunohistochemistry.Results:The inflammation of periodontal tissues in P1 ,P2 were improved more than that in P0 .AL in group P2 were lower than that in other groups(P <0.05).The IL-6 expres-sion in periodontal tissues and the levels of serum hs-CRP and IL-6 of group P2 were lower than those of other groups(P <0.05).Ser-um hs-CRP level was positively correlated with IL-6 level.Conclusion:Gegen Qinlian decoction may inhibit the development of peri-odontitis by depressing the expression of serum hs-CRP and IL-6.
