The effects of resveratrol on the express of inflammatory factors of human umbilical vein endothelial cells induced by Aβ1 -42
10.3969/j.issn.1671-8348.2015.32.006
- VernacularTitle:白藜芦醇对β淀粉肽1～42刺激内皮细胞炎症因子表达的影响
- Author:
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
endothelial cell;
resveratrol;
beta amyloid peptide 1 -42;
inflammatory factors
- From:
Chongqing Medicine
2015;(32):4481-4482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of resveratrol on the express of inflammatory factors (IL‐1 ,IL‐6 ,TNF‐α)of hu‐man umbilical vein endothelial cells(HUVEC) induced by Aβ1 -42 .Methods HUVEC were stimulated with Aβ1 -42 5 × 101 μmol/L , last 24 h and administrated with resveratrol 160 ,80 ,40 ,20 μg/L ,HUVEC viability were detected by CCK‐8 ;the concentration of IL‐1 ,IL‐6 and TNF‐α were detected by ELISA .Results Compared with model group ,160 ,80 ,40 ,20 μg/L resveratrol could in‐crease HUVEC survival rate ,reduced HUVEC damage by Aβ1 -42 ,inhibited the concentration of IL‐1 ,IL‐6 and TNF‐α(P<0 .05) . Conclusion Resveratrol over 20 μg/L could reduce the release of IL‐1 ,IL‐6 and TNF‐αof HUVEC inducing by Aβ1 -42 .
