Clinical factors and prognostic significance of skeletal related events in bone metastasis of non small cell lung cancer in 223 cases
10.3969/j.issn.1671-8348.2015.32.014
- VernacularTitle:223例非小细胞肺癌骨转移发生骨相关事件的临床因素与预后
- Author:
Shuai WANG
;
Qian LI
;
Yi QING
;
Zhaoyang ZHONG
;
Jinlu SHAN
;
Wei GUAN
;
Xueqin YANG
;
Ge WANG
;
Zhenzhou YANG
;
Dong WANG
- Publication Type:Journal Article
- Keywords:
cancer,non small cell lung;
bone metastasis;
skeletal related events
- From:
Chongqing Medicine
2015;(32):4504-4506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of skeletal related events (SREs) in non small cell lung cancer with bone metastases and its effect on the prognosis .Methods Totally 223 cases of NSCLC patients with bone metastasis were retrospective studied from January 2010 to December 2012 in our hospital .The clinical features ,predictive factors for SREs were analysed by sin‐gle factor and multifactor analysis .Results Among 223 cases of NSCLC patients with bone metastasis ,119 cases occured with SREs(53 .4% ) .Univariate analysis showed that the occurrence of SREs in female ,no smoker ,adenocarcinoma ,solitary bone metas‐tasis lesions were less than the male ,smoker non‐adenocarcinoma ,and multiple bone metastases (P<0 .05) ,but the rost without statistically significant(P>0 .05) .The multivariate analysis revealed only multiple bone metastases was an independent risk factor for SREs .The median survival time of the NSCLC patients with bone metastasis was 15 .3 months .Moreover ,survival analysis showed that SREs had no statistical significance on the prognosis of bone metastasis in NSCLC patients (P>0 .05) .Conclusion The female ,adenocarcinoma ,smoking history ,solitary bone metastasis lesions occurred in patients with lower risk SREs .Multiple bone metastasis is an independent risk factor for SREs ,attention should be paid to monitoring and prevention .
