The study of low doses 131 I on serum levels of ghrelin and related serological indexes in patients with grave′s disease
10.3969/j.issn.1671-8348.2015.32.024
- VernacularTitle:低剂量131I对Graves病患者血清Ghrelin水平及相关血清学指标的影响研究
- Author:
Ling MA
- Publication Type:Journal Article
- Keywords:
iodine;
Graves′disease;
Ghrelin levels
- From:
Chongqing Medicine
2015;(32):4529-4531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the low doses of 131 iodine on serum Ghrelin levels and serological related indexes in pa‐tients with hyperthyroid .Methods A randomized controlled trials ,96 cases of hyperthyroidism in our hospital were randomly divid‐ed into two groups (group A and group B)according to the ratio of 1∶1 from June 2011 to June 2012 ,48 cases in each group ,and at the same time ,42 cases health people as health control group .The group A were treated with 131 iodine solution 3 .69 -4 .40 MBq/g reatment ,group B was given 131 iodine solution 2 .59-2 .96 MBq/g treatment ,and the serum Ghrelin levels and serological related indicators of two groups patients were statistically analyzed after treatment .Followed up for 2 years ,review of the serum levels of Ghrelin and serological related indexes and compare the incidence of hypothyroidism .Results The serum FT3 ,FT4 and FPG levels of hyperthyroid patients were significantly higher than the health control group (P< 0 .01);conversely ,the serum S‐TSH and Ghrelin levels of hyperthyroid patients were significantly lower than the health control group (P<0 .01) .3 months later after treatment ,the serum FT3 ,FT4 and FPG levels of the hyperthyroidism group B were significantly lower than hyperthyroidism group A(P<0 .05);on the contrary ,the serum Ghrelin and S‐TSH levels were significantly higher and hyperthyroidism group A (P<0 .05);2‐year follow‐up after treatment ,the incidence of hypothyroidism of hyperthyroidism group A were higher and group B ,but without statistical significance(P>0 .05) .Conclusion A low dose of oral 131 iodine solution (2 .59‐2 .96 MBq/g) ,could get a better short‐term efficacy in patients with hyperthyroidism ,high security .
