The clinical expression significance of PD-L1 on the CD4+CD25hi CD127low/- Treg cells in the peripheral blood of colon cancer
10.3969/j.issn.1671-8348.2015.31.002
- VernacularTitle:PD-L1在结肠癌患者CD4＋CD25hiCD127low／-调节性 T 细胞中的表达及其临床意义
- Author:
Jiaojiao LIANG
;
Songwen JU
;
Zhixin GAO
- Publication Type:Journal Article
- Keywords:
PD-L1;
colonic neoplasms;
T-lymphocytes,regulatory;
CD4+CD25hiCD127low/-
- From:
Chongqing Medicine
2015;(31):4324-4326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of PD‐L1 in the CD4+CD25hiCD127low/‐ Treg cells in the peripheral blood of colon cancer and the correlation with clinical stage .Methods The expression of PD‐L1 on CD4+CD25hiCD127low/‐Treg cells from 47 samples of the peripheral blood of colon cancer was analyzed by flow cytometry .Results Compared with those from healthy do‐nor ,the proportion of CD4+CD25hiCD127low/‐Treg cells and expression of PD‐L1 on these cells increased significantly (P<0 .01) . Further analysis showed that expression of PD‐L1 increased with the increase of clinical stage of colon cancer (P<0 .01) ,and de‐creased significantly after postoperation (P<0 .05) .Conclusion Increase of proportion of CD4+CD25hiCD127low/‐Treg cells and the expression of PD‐L1 may enhance the suppression of antitumor immunity ,and thereby promote tumor immunoescape .
