Predictive value of detection of serum Cys -C and hs -CRP in cardiovascular adverse events in patients with primary hypertension
10.3760/cma.j.issn.1008-6706.2015.23.005
- VernacularTitle:血清胱抑素C和超敏C反应蛋白检测对原发性高血压患者并发心脑血管不良事件的预测价值
- Author:
Jie ZHOU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Cys -C;
C -reactive protein
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(23):3536-3538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of detection of serum Cys -C and hs -CRP in cardio-vascular adverse events of patients with primary hypertension.Methods 138 patients with hypertension were selected and their serum Cys -C and hs -CRP levels were detected.Patients were given conventional treatment and blood pressure was controlled stably.Two years later,patients were divided into stable group(96 cases)and progression group(42 cases)according to the occurrence of cardiovascular adverse events,additionally,42 people received physi-cal examination in corresponding period were selected as control group.The levels of serum Cys -C and hs -CRP were detected again.The detection results and complications were analyzed retrospectively.Results For initial detec-tion,the levels of serum Cys -C[(0.87 ±0.39)mg/L,(1.16 ±0.47)mg/L]and hs -CRP[(1.79 ±0.56)mg/L, (2.26 ±0.91)mg/L]in the stable and progression groups were higher than the control group[(0.59 ±0.32)mg/L, (0.68 ±0.37)mg/L],and those in the progression group were higher than the stable group(t =2.162,3.904, 5.237,6.441,all P <0.01).For the reexamination,the levels of serum Cys -C[(1.39 ±0.41)mg/L]and hs -CRP [(3.37 ±0.89)mg/L]in the progression group were higher than the stable group[(0.92 ±0.43)mg/L,(1.83 ± 0.62)mg/L](t =2.958,5.119,all P <0.01).The levels of serum Cys -C and hs -CRP in the stable group after 2 years were similar to those at initial detection(t =0.331,0.414,all P >0.05),but the levels in the progression group increased obviously(t =2.146,3.144,all P <0.01).Conclusion The levels of serum Cys -C and hs -CRP were closely related to disease progression and prognosis.And the detection of them can predict the progression of disease,conductive to taking intervening measures for the early stage.
