Primary Squamous Cell Carcinoma of the Upper Genital Tract: Utility of p16INK4a Expression and HPV DNA Status in its Differential Diagnosis from Extended Cervical Squamous Cell Carcinoma.
- Author:
Su Hyun YOO
1
;
Eun Mi SON
;
Chang Okh SUNG
;
Kyu Rae KIM
Author Information
1. Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Carcinoma, squamous cell;
Genes, p16;
DNA probes, HPV
- MeSH:
Carcinoma, Squamous Cell*;
Cervix Uteri;
Diagnosis, Differential*;
DNA Probes, HPV;
DNA*;
Endometrium;
Fallopian Tubes;
Female;
Genes, p16;
Humans;
Hysterectomy;
Mucous Membrane;
Neoplasm Staging;
Ovary
- From:Korean Journal of Pathology
2013;47(6):549-556
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Primary squamous cell carcinoma (SCC) of the upper genital tract, including the endometrium, fallopian tubes, and ovaries, is extremely rare. It must be distinguished from the mucosal extension of primary cervical SCC because determination of the primary tumor site is important for tumor staging. However, patients with SCC of the fallopian tubes or ovarian surface have often undergone prior hysterectomy with inadequate examination of the cervix, making it difficult to determine the primary site. METHODS: We compared histologic findings, p16INK4a expression, and human papillomavirus (HPV) DNA status in four patients with primary SCC of the upper genital tract and five patients with primary cervical SCC extending to the mucosa of the upper genital tract. RESULTS: All five SCCs of cervical origin showed strong expression of p16INK4a, whereas all four SCCs of the upper genital tract were negative, although one showed weak focal staining. Three of the five cervical SCCs were positive for HPV16 DNA, whereas all four primary SCCs of the upper genital tract were negative for HPV DNA. CONCLUSIONS: Although a thorough histological examination is important, immunonegativity for p16INK4a and negative for HPV DNA may be useful adjuncts in determining primary SCCs of the upper genital tract.
