The effect of alpha lipoic acid and Shuxuetong on islet function in patient with type 2 diabetes mellitus
10.3969/j.issn.1671-8348.2015.25.027
- VernacularTitle:α-硫辛酸联合疏血通对2型糖尿病患者胰岛功能的影响
- Author:
Feng JU
;
Maoxiong FU
;
Qiaofan WANG
;
Zurong WU
;
Longyuan HAN
;
Yalian HUANG
- Publication Type:Journal Article
- Keywords:
alpha lipoic acid;
type 2 diabetes mellitus;
oxidative stress;
insulin resistance;
Shuxietong
- From:
Chongqing Medicine
2015;(25):3536-3538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of alpha lipoic acid and Shuxuetong on oxidative stress and insulin resistance in patient with type 2 diabetes mellitus(T2DM)and to guide the clinical therapy for T2DM.Methods Totally 90 cases of T2DM pa-tients were sellected from Hainan Province Nongken Hospital.The patients were divided into Shuxuetong group(group A,n=30), alpha lipoic acid group(group B,n=30)and alpha lipoic acid and Shuxuetong group(group C,n =30).HOMA-IR,HOMA-β,and HOMA-ISI was calculated.SOD was determined by xanthine oxidase method.MDA was detected by Thiobarbituric acid method. The expression of IL-6 and TNF-αwas determined by ELISA analysis.Results Before treatment,SOD,MDA,IL-6,TNF-α,HO-MA-IR,HOMA-ISI,and HOMA-βwas no significant difference among the three groups(P >0.05).After treatment,all of which was significantly changed(P <0.05 and P <0.01).SOD,HOMA-ISI and HOMA-βin group C was significantly higher than that in group B(P <0.05),and which was significantly higher in group B than that in group A (P <0.05).MDA and HOMA-IR in group C was significantly lower than that in group B(P <0.05),and which was significantly lower in group B than that in group A (P <0.05).IL-6 and TNF-αin group C was lower than that in group A and group B(P <0.01),and which was no significant difference between group A and group B(P >0.05).Conclusion Alpha lipoic acid combined with Shuxuetong injection can significantly im-prove the oxidative stress state of T2DM patients,inhibit the inflammatory reaction,improve insulin resistance and patient′s sensi-tivity to insulin.Which was contribute to clinical treatment for T2DM.
