NT-proBNP,hs-CRP and echocardiography:predictive value for the degree of coronary artery lesion
10.3969/j.issn.1671-8348.2015.31.007
- VernacularTitle:NT-proBNP、hs-CRP和超声心动图与急性冠状动脉综合征病变程度的相关性研究
- Author:
Fengyun CHEN
;
Hua XIAO
- Publication Type:Journal Article
- Keywords:
acute coronary syndrome;
natriuretic peptide,brain;
C-reative protein;
cardiac output;
degress of coronary arterial stenosis
- From:
Chongqing Medicine
2015;(31):4338-4342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between NT‐proBNP ,hs‐CRP level ,echocardiography and early avascu‐lar necrosis of coronary artery syndrome (ACS) ,coronary artery lesion degree .Methods 142 patients admitted in this hospital for chest pain from March 2013 to February 2014 were enrolled ,and all patients′history ,electrocardiogram (ECG) ,plasma levels of N‐terminal pro‐Brain Natriuretic Peptide (NT‐proBNP) ,hypersensitive C‐reative protein (hs‐CRP) and cTnT were recorded or tested within 24 hours ,while left ventricular ejection fraction (LVEF) and left ventricular end‐diastolic diameter (LVEDd) were recorded by echocardiography .According to the history and coronary angiography results conducted during hospitalization ,patients were di‐vided into acute ST segment elevation myocardial infarction (STEMI) group ,acute non‐ST segment elevation myocardial infarction (NSTEMI) group ,unstable angina pectoris (UA) group and control group (normal coronary angiography ,cTnT and ECG) .Pa‐tients with abnormal coronary angiography results were further divided into single vessel lesion group ,double vessel lesion group and triple vessel lesion group .The differences of plasma NT‐proBNP level ,hs‐CRP level and LVEF in each group ,and multivariate linear regression analysis were conducted to find out the independent risk factors for elevated plasma NT‐proBNP .Results 102 ACS patients and 40 normal patients were enrolled .Plasma levels of NT‐proBNP ,hs‐CRP and LVEF in NSTEMI group (n=30) and STEMI group (n=32) were significant different from UA group (n=40) and control group (n=40) respectively (P<0 .05) . The NT‐proBNP levels in control group and triple vessel lesion group (n=41) were respectively significant different from both sin‐gle vessel lesion group (n=30) and double vessel lesion group (n=31) (P<0 .05) .Multivariate linear regression analysis showed that ,plasma hs‐CRP level (P=0 .007) ,coronary artery lesion degree (P=0 .00) and history of diabetes (P=0 .006) were positive associated factors of NT‐proBNP level ,while LVEF was the negative associated factors of NT‐proBNP level(P=0 .036) .Conclusion Plasma NT‐proBNP level ,hs‐CRP level and LVEF are closely related to ACS ,and they might play an important role in determi‐ning the extent of early ischemic necrosis and clinical classification .Plasma NT‐proBNP level could be an important molecular mark‐er to reflect the degree of coronary artery lesion .
