Composite Pheochromocytoma or Paraganglioma of Adrenal Gland: A Case Report with Immunohistochemical Studies and Electron Microscopic Examination.
10.4132/KoreanJPathol.2011.45.3.306
- Author:
Hyeyoon CHANG
1
;
Hoiseon JEONG
;
Younghye KIM
;
Sung Hye PARK
;
Aeree KIM
Author Information
1. Department of Pathology, Korea University Guro Hospital, Korea University School of Medicine, Seoul, Korea. ark@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Composite pheochromocytoma and ganglioneuroma, Pheochromocytoma;
Paraganglioma;
Adrenal glands
- MeSH:
Adrenal Glands;
Adult;
Electrons;
Epinephrine;
Female;
Ganglion Cysts;
Ganglioneuroma;
Humans;
Korea;
Melanins;
Neurofilament Proteins;
Norepinephrine;
Paraganglioma;
Pheochromocytoma;
S100 Proteins;
Schwann Cells;
Silver Nitrate;
Synaptophysin
- From:Korean Journal of Pathology
2011;45(3):306-310
- CountryRepublic of Korea
- Language:English
-
Abstract:
Composite pheochromocytoma or paraganglioma of the adrenal gland is a well-recognized, yet extremely rare tumor with only one case reported in Korea. We report a case of incidentally found composite pheochromocytoma and ganglioneuroma of the adrenal gland in a 44-year-old female composed of intermingled components of pheochromocytom, ganglioneuroma, and cells with intermediate features. On immunohistochemical staining, the pheochromocytoma component was positive for synaptophysin and chromogranin, but negative for S-100 protein. Staining for the S-100 protein revealed sustentacular cells which formed a peripheral coat around the "Zellballen" and Schwann cells. The Fontana-Masson stain defined neuromelanin granules of ganglion cells and the ganglion cells expressed neural markers such as neurofilament proteins. Ultrastructural findings revealed pheochromocytes with a round or ovoid nucleus and occasionally prominent nucleolus containing numerous adrenaline and noradrenaline granules.
