Solitary Fibrous Tumor of the Conjunctiva with Heretofore Undescribed Pathologic Findings.
10.4132/KoreanJPathol.2011.45.3.315
- Author:
Na Rae KIM
1
;
Jae Y RO
;
Kyung Hwan SHIN
;
Hae Jung PAIK
;
Jung Suk AN
;
Seung Yeon HA
Author Information
1. Department of Pathology, Gachon University Gil Hospital, Incheon, Korea. syha@gilhosptial.com
- Publication Type:Case Report
- Keywords:
Solitary fibrous tumors;
Conjunctiva;
Antigens, CD34;
CD99;
Bcl-2
- MeSH:
Actins;
Adult;
Antigens, CD34;
Basement Membrane;
Biopsy;
Chimera;
Conjunctiva;
Cytoplasm;
Desmin;
Diagnosis, Differential;
Electrons;
Endoplasmic Reticulum, Rough;
Eosinophils;
Female;
Fibroblasts;
Glial Fibrillary Acidic Protein;
Glomus Tumor;
Humans;
Leiomyoma;
Light;
Melanoma;
Meningioma;
Mitochondria;
Mucin-1;
Muscle, Smooth;
Nevus;
Ribosomes;
S100 Proteins;
Solitary Fibrous Tumors;
Vimentin
- From:Korean Journal of Pathology
2011;45(3):315-318
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.
