Progress on epigenetic regulation of long noncoding RNAs in cardiac development and heart diseases
10.3969/j.issn.1000-4718.2015.11.029
- VernacularTitle:长链非编码 RNA 对心脏发育的表观遗传学调控研究进展
- Author:
Xiangyu YANG
;
Xiyong YU
- Publication Type:Journal Article
- Keywords:
Long noncoding RNAs;
Cardiac development;
Heart diseases;
Epigenetics
- From:
Chinese Journal of Pathophysiology
2015;(11):2101-2106
- CountryChina
- Language:Chinese
-
Abstract:
It was previously revealed that noncoding RNAs, especially microRNAs, control cardiac genes and regulate heart function.Recently, growing evidence from high-throughput genomic platforms has confirmed that long non-coding RNAs ( lncRNAs) serve as new and enigmatic regulators in cardiac development and homeostasis.Nevertheless, lit-tle is known about their characteristics compared to microRNAs.Here, we review the latest progress on lncRNAs in cardiac biology and diseases, summarizing detailed knowledge of their functions and novel cardiac-related gene regulatory mecha-nisms in epigenetic processes.Finally, we highlight that lncRNAs could be promising therapeutic targets and diagnostic bi-omarkers in cardiac pathophysiology.
