Serum TK1 and its relation to the clinicopathological features and prognosis of patients with lung cancer

VernacularTitle:肺癌患者血清TK1水平与临床病理学特点及预后关系的研究
Author: Heng YE ; Keqing QIAN ; Wei HUANG
Publication Type:Journal Article
Keywords: lung cancer; cytoplasm thymidine kinase 1; prognosis
From: Chinese Journal of Clinical Oncology 2015;(21):1047-1049
CountryChina
Language:Chinese
Abstract: Objective:This study investigated the positive detection rate of cytoplasm thymidine kinase 1 (TK1) in lung cancer patients and the relationship of TK1 with clinicopathological features and prognosis. Methods:Sensitive chemiluminescence dot-blot assay was used to detect serum TK1 levels in 73 lung cancer patients and 56 normal control subjects. Results:The positive detection rate of TK1 was elevated in the lung cancer patients compared with the controls (P=0.006). The positive detection rate of TK1 was also correlated with distant metastases, but not with other factors, such as smoking, sex, lymph node metastasis, and pathology types. The 2 year survival of the patients with negative TK1 detection was significantly longer than that of the patients positively detected with the marker (P<0.001). Conclusion:Serum TK1, a new tumor marker, has potential applications in the diagnosis and prognosis of lung cancer.