Effects of eucommia alcohol extract on a rabbit model of mandibular distraction osteogenesis
10.3969/j.issn.2095-4344.2015.42.001
- VernacularTitle:杜仲醇提取物对兔下颌牵张成骨的影响
- Author:
Xiaowen JIANG
;
Yi ZHANG
;
Xiaosheng FAN
;
Xuan DENG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;(42):6725-6729
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Long course of treatment and complications limit the extensive application of distraction osteogenesis, which cannot meet the clinical requirements. OBJECTIVE:To investigate the effect of general administration of eucommia alcohol extract on new bone regeneration based on the rabbit model of mandibular distraction osteogenesis. METHODS:Twenty-four New Zealand white rabbits were randomly divided into experimental group and control group. Unilateral mandibular distraction osteogenesis model was established by 1 mm/12 h distraction protocol. During the distraction period, the rabbits in the experimental group were intragastricaly administered with eucommia alcohol extract and the control animals received the same amount of physiological saline, respectively. Six weeks later, the animals were sacrificed for osteogenic testing. RESULTS AND CONCLUSION: New bone formation was observed in the distracted gap in both groups. However, the amount, mineralization and biomechanical strength of new regenerated bone in the experimental group were obviously greater than those in the control group by histological observation, dual energy X-ray absorptiometry, micro-CT and biomechanical test. General administration of eucommia alcohol extract can markedly promote distraction osteogensis in rabbit mandibular osteodistraction.
