Comparative Efficacy of Ivermectin and Levamisole for Reduction of Migrating and Encapsulated Larvae of Baylisascaris transfuga in Mice.
10.3347/kjp.2011.49.2.145
- Author:
Yan FU
1
;
Hua Ming NIE
;
Li Li NIU
;
Yue XIE
;
Jia Bo DENG
;
Qiang WANG
;
Guang You YANG
;
Xiao Bin GU
;
Shu Xian WANG
Author Information
1. Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China. guangyou1963@yahoo.com.cn
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Baylisascaris transfuga;
ivermectin;
levamisole;
migrating larvae;
encapsulated larvae;
granuloma
- MeSH:
Animals;
Anthelmintics/*administration & dosage;
Ascaridida Infections/*drug therapy/parasitology;
Ascaridoidea/*drug effects;
Disease Models, Animal;
Female;
Ivermectin/*administration & dosage;
Larva/drug effects;
Levamisole/*administration & dosage;
Male;
Mice;
Mice, Inbred BALB C;
Rodent Diseases/drug therapy/parasitology;
Treatment Outcome
- From:The Korean Journal of Parasitology
2011;49(2):145-151
- CountryRepublic of Korea
- Language:English
-
Abstract:
The comparative efficacy of 2 anthelmintics (ivermectin and levamisole) against Baylisascaris transfuga migrating and encapsulated larvae was studied in mice. A total of 60 BALB/c mice inoculated each with about 1,000 embryonated B. transfuga eggs were equally divided into 6 groups (A-F) randomly. Mice of groups A and B were treated with ivermectin and levamisole, respectively, on day 3 post-infection (PI). Mice of groups A-C were killed on day 13 PI. Similarly, groups D and E were treated with ivermectin and levamisole, respectively, on day 14 PI, and all mice of groups D-F were treated on day 24 PI. The groups C and F were controls. Microexamination was conducted to count the larvae recovering from each mouse. The percentages of reduction in the number of migrating larvae recovered from group A (ivermectin) and B (levamisole) were 88.3% and 81.1%, respectively. In addition, the reduction in encapsulated larvae counts achieved by ivermectin (group D) and levamisole (group E) was 75.0% and 49.2%, respectively. The results suggested that, to a certain extent, both anthelmintics appeared to be more effective against migrating larvae than encapsulated larvae. However, in the incipient stage of infection, ivermectin may be more competent than levamisole as a larvicidal drug for B. transfuga.
