The Predictive Value of Coronary Flow Reserve in Diagnosing Coronary Stenosis by Transthoracic Doppler Echocardiography in Patients of Hypertension
10.3969/j.issn.1000-3614.2015.10.005
- VernacularTitle:经胸多普勒超声心动图检测冠状动脉血流储备对高血压患者冠状动脉狭窄的预测价值
- Author:
Weihong LI
;
Zhaoping LI
;
Weixian XU
;
Xiaowei MA
;
Xinheng FENG
- Publication Type:Journal Article
- Keywords:
Coronary lfow reserve;
Transthoracic Doppler echocardiography;
ATP stress echocardiography;
Hypertension;
Coronary stenosis
- From:
Chinese Circulation Journal
2015;(10):946-949
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the predictive value of coronary lfow reserve (CFR) for diagnosing coronary stenosis by transthoracic Doppler echocardiography (TTDE) in patients with hypertension.
Methods: A total of 132 patients scheduled for elective coronary angiography (CAG) due to chest pain were enrolled. The patients were divided into 2 groups: Hypertension group,n=95 and Non-hypertension group,n=37. The CRF of left anterior descending coronary artery (LAD) was measured by ATP stress TTDE at 2 days before CAG in all patients and the results were compared between 2 groups. ROC curve was conducted to assess CFR value in diagnosing LAD stenosis which was deifned by LAD luminal diameter stenosis ≥ 70% in relevant patients.
Results: The condition of LAD stenosis was similar between 2 groups (42.1% vs. 35.1%),P>0.05. The CFR value in Hypertension group was lower than that in Non-hypertension group (2.39 ± 0.86) vs. (2.87 ± 1.12),P<0.05. The ROC curve for diagnosing LAD stenosis in all patients were at 0.884 (95% CI 0.83-0.94,P<0.0001), in Hypertension group at 0.874 (95% CI 0.81-0.94,P<0.0001) and in Non-hypertension group at 0.915 (95% CI 0.82-0.98,P<0.0001). With the cut-off point of CFR ≤ 2.2, it had the diagnostic sensitivity, speciifcity and accuracy in all patients were at 80.3%, 83.5% and 80.3%; in Hypertension group were at 77.5%, 80.0% and 78.9%, in Non-hypertension group were at 69.2, 91.7% and 83.8% respectively.
Conclusion: The patients of hypertension combining chest pain had decreased CFR which implied the dysfunction of their microcirculation. CFR had the better diagnostic value for predicting the signiifcant LAD stenosis in such patients.
