Relationship between genetic polymorphism of transcription factor 7-like 2 and genetic susceptibility to type 2 diabetes mellitus in Uygur population of Xinjiang region
- VernacularTitle:转录因子7类似物2基因多态性与新疆维吾尔族人群2型糖尿病遗传易感性的关系
- Author:
Zhiqiang WANG
;
Qi MA
;
Tingting WANG
;
Yinxia SU
;
Yan MA
;
Jun ZHU
;
Hua YAO
- Publication Type:Journal Article
- Keywords:
polymorphisms;
TCF7L2 gene;
type2 diabetes mellitus;
Uygur
- From:
Basic & Clinical Medicine
2015;(9):1162-1166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the potential association of transcription factor 7-like 2(TCF7L2 polymorphisms with type 2 diabetes mellitus in Uygur population of Xinjiang region .Methods In this case-control study ,819 ca-ses of type 2 diabetes mellitus patients were recruited in case group and 731 healthy individuals were selected as control.5 mL of blood sample were collected from each subject .The polymorphism was examined by matrix-assis-ted laser desorption/ionization-time of flight ( MALDI-TOF) and the OR value (95%CI) was evaluated by Logistic Regression Method to analyze the relationship between susceptibility to type 2 diabetes mellitus and different geno-types.Results In case group, the frequencies of TC, CC genotype and C allele at rs7901695 were higher than the corresponding frequencies in control group (P<0.05).The interaction between TCF7L2 and environment risk factors did not contribute to the occurrence of the type 2 diabetes mellitus .Conclusions The polymorphisms of rs7091695 in TCF7L2 but not rs7085532 in TCG7L2 may be associated with type 2 diabetes mellitus in Uygur pop-ulation in Xinjiang region .
