The distribution of gene polymorphism of methylenetetrahydrofolate reductase and methionine synthase among Han women in Zhangjiagang city
- VernacularTitle:张家港市汉族女性MTHFR与MTRR基因多态性分布
- Author:
Xinxin LI
;
Yanqiang LU
;
Shaojie MA
;
Mingxia GONG
;
Yaqin YUAN
;
Yunxia HUANG
;
Zhongliang ZHANG
;
Qi YANG
- Publication Type:Journal Article
- Keywords:
methylenetetrahydrofolate reductase;
methionine synthase reductase;
single nucleotide polymorphisms
- From:
Basic & Clinical Medicine
2015;(9):1228-1231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the 5,10-methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydro-folate-homocysteine methyltransferase reductase ( MTRR ) gene polymorphisms among the Han women in Zhangjiagang city .Methods A total of 4008 Han women were recruited .Their oral epithelial cells were collected to extract genome DNA in order to detect gene polymorphisms of MTHFR and MTRR using fluorescence quantitative PCR.Then the results were compared with those in other cities in China .Results The genotype frequencies of MTHFR C677T CC, CT and TT among Zhangjiagang women are 32.2%, 49.5%and 18.3%, respectively.The C allele frequency is 64.3%, T allele frequency is 35.7%.The genotype frequencies of MTHFR A1298 C AA, AC and CC are 68.7%,28.7% and 2.5%, respectively .The A allele frequency is 80.8%, C allele frequency is 19.2%.The genotype frequencies of MTRR A66 G AA, AG and GG are 54.4%, 38.5%and 7.1%, respectively . The A allele frequency is 76.3%, G allele frequency is 26.4%.Conclusions The MTHFR, MTRR polymorphism distribution of Han women in Zhangjiagang city is region specific.
