Expression and significance of TSP-1 and BMP-7 in nasal mucosa of chronic rhinosinusitis
- VernacularTitle:TSP-1与BMP-7在慢性鼻-鼻窦炎鼻黏膜组织中的表达及意义
- Author:
Jinrong FAN
;
Chunhua DAI
- Publication Type:Journal Article
- Keywords:
sinusitis;
TSP-1;
BMP-7;
TGF-β1;
tissue remodeling
- From:
Basic & Clinical Medicine
2015;(9):1261-1263
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of thrombospondin-1 ( TSP-1 ) and bone morphogenetic protein-7 ( BMP-7 ) in mucus membrcane of chronic rhinosinusitis ( CRS ) and its potential significance in pathogenesis . Methods TSP-1 ,BMP-7 and TGF-β1 were detected by ELISA .Results The expression level of TSP-1 and TGF-β1 increased gradually with the advanced stage of CRSsNP ( P<0.05 ) .The expression of BMP-7 decreased gradu-ally with the advanced stage of CRSsNP ( P<0.05 ) .The expression of TSP-1 and TGF-β1 decreased gradually with the advanced stage of CRSwNP ( P<0.05 ) .The expression level of BMP-7 increased gradually with the ad-vanced stage of CRSwNP ( P<0.05 ) .Conclusions The expressions of TSP-1 and BMP-7 were abnormal in nasal mucosa of CRS , which might be involved in the pathogenesis of CRS .
