Advances in research on ARID1 A in Malignancies
- VernacularTitle:ARID1 A在恶性肿瘤中的研究进展
- Author:
Zengfa GAO
;
Yongna WU
;
Xun LI
- Publication Type:Journal Article
- Keywords:
ARID1A;
chromatin remodeling;
tumor suppressor gene;
malignant tumor
- From:
Basic & Clinical Medicine
2015;(9):1267-1270
- CountryChina
- Language:Chinese
-
Abstract:
SWI/SNF is an ATP-dependent chromatin remodeling complex .ARID1 A gene is an important subunit of SWI/SNF complex and its dysfunction can cause abnormal chromatin remodeling , resulting in tumorigenesis .AR-ID1A occurs frequently low expression or deletion mutation in a variety of malignant tumors , such as ovarian canc-er, liver cancer, breast cancer, stomach cancer, lung cancer and so on, which indicates that ARID1A is an impor-tant tumor suppressor gene .
