Therapeutic effect of the combined treatment of mecobalamin and salvia miltiorrhiza ligustrazine on diabetic peripheral neuropathy
10.3760/cma.j.issn.1008-6706.2015.22.034
- VernacularTitle:甲钴胺联合丹参川芎嗪治疗糖尿病周围神经病变的作用
- Author:
Zhongmei JIANG
;
Zhuanxin CHEN
- Publication Type:Journal Article
- Keywords:
Mecobalamin;
Salvia miltiorrhiza ligustrazine;
Diabetic peripheral neuropathy;
Sensory nerve conduction velocity (SNCV);
Motor nerve conduction velocity (MNCV)
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(22):3467-3469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To learn therapeutic effect of the combined treatment of mecobalamin and salvia milti-orrhiza ligustrazine on diabetic peripheral neuropathy.To provide effective and reliable operation method for the treat-ment of disease.Methods 163 cases with diabetic peripheral neuropathy were randomly divided into observation group(86 cases)and control group(77 cases).The observation group was treated with mecobalamin combined salvia miltiorrhiza ligustrazine,the control group was treated with mecobalamin.The sensory conduction velocity (SNCV) and motor conduction velocity (MNCV)were measured in the two groups before and after treatment.The therapeutic effects were evaluated after one course.Results The MNCV and SNCV of the two groups were higher than before treatment,the difference was statistically significant (t =24.298,25.546,18.737,15.733,14.284,14.886,9.337, 9.402,all P <0.05).The SNCV and MNCV in the observation group were significantly higher than those in the con-trol group (t =9.119,11.103,7.429,6.352,all P <0.05).The markedly effective rate of the observation group was 48.8% (42 /86),the total effective rate was 90.7% (78 /86),which were higher than those of the control group,the differences were statistically significant (χ2 =9.010,7.937,all P <0.05).The incidence rate of adverse reaction of the observation group was 5.8% (5 /86),which of the control group was 6.5% (5 /77),the difference was not statis-tically significant (χ2 =0.033,P >0.05).Conclusion In the treatment of diabetic peripheral neuropathy,the com-bined treatment of mecobalamin and salvia miltiorrhiza ligustrazine has better curative effect and low incidence rate of adverse reaction,with good clinical application value.
