Roles of IL-23/IL-17 axis in pathogenesis and treatment of ankylosing spondylitis
10.11958/j.issn.0253-9896.2015.10.034
- VernacularTitle:IL-23/IL-17轴在强直性脊柱炎发病中的作用及治疗意义研究进展
- Author:
Chao CHEN
;
Jianjun LI
- Publication Type:Journal Article
- Keywords:
spondylitis,ankylosing;
interleukin-23;
interleukin-17;
immunotherapy;
review;
IL-23/IL-17 axis
- From:
Tianjin Medical Journal
2015;(10):1213-1216
- CountryChina
- Language:Chinese
-
Abstract:
The treatments for ankylosing spondylitis (AS) are still not effective, which partially due to its unclear patho?genesis. Interleukin (IL)-23/IL-17 axis is a significant immunologic pathway which has attracted much attention in the past few years. This article reviewed the role of IL-23/IL-17 axis in genetic and immunological pathogenesis of AS, and intro?duced the recent progresses in treatments of AS using anti-IL-23 or anti-IL-17 antibody. The important role of IL-23/IL-17 axis in the pathogenesis and treatment of AS indicates its potential use as a new therapeutic target.
