Analysis of correlation between NKG2D receptor pathway and the mechanism of DNT cell' killing effect
10.3760/cma.j.issn.1673-4203.2015.06.022
- VernacularTitle:NKG2D受体通路与DNT细胞杀伤作用的关联性分析
- Author:
Xingxing ZHU
;
Jiong CHEN
- Publication Type:Journal Article
- Keywords:
Immunity,cellular;
Pancreatic neoplasms;
DNT cell;
NKG2D Receptor
- From:
International Journal of Surgery
2015;42(6):429-432
- CountryChina
- Language:Chinese
-
Abstract:
NKG2D is an activating receptor expressed on various immune cells' surfaces.Currently,eight ligands have been found,they can be divided into two kinds:MHC Ⅰ related protein and ULBP molecules.NKG2D receptors and their respective ligands differentially exist in normal and cancerous tissues.So far,many researchers have found that a lot of immune cells' anti-tumor mechanism is mediated by NKG2D receptor and it can't be replaced in the resistance to the development of carcinoma.adoptive immunotherapy is a new method of treating cancer that propose to find tumor-specific cytotoxicity immune cells and enlarge the amount of it,then injected into human body to resist tumor.Recently,many researchers have found that DNT cells (CD4-CD8-T 细胞)have the function of anti-tumor;sadly its mechanisms are unclear.After the summary of NKG2D receptor-mediated pathway of destruction,this paper try to analyze its relevance to DNT cells' killing effect,on the purpose of finding the Killing mechanism of DNT cells that may existed.
