Haemodynamic analysis in canine aneurysm model
10.11958/j.issn.0253-9896.2015.10.013
- VernacularTitle:犬动脉瘤动物模型的血流动力学分析
- Author:
Hao LI
;
Bo MA
;
Zhiqiang LI
;
Qihong WANG
- Publication Type:Journal Article
- Keywords:
hemodynamics;
intracranial aneurysm;
animal models
- From:
Tianjin Medical Journal
2015;(10):1133-1136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore a way to establish a stable, ideal and handy intracranial aneurysm model for related studies. Methods Modified microsurgery technology was applied to establish sidewall, bifurcation, terminal and merged types of aneurysm (n=7 in each type). Two weeks after operation, color Doppler ultrasound, magnetic resonance imaging (MRI), magnetic resonance angiography (MRA) and intra-arterial digital subtraction angiography (IADSA) were performed and computational fluid dynamics (CFD) was used for simulation analysis of aneurysm models. Biomechanical properties of aneurysm wall tissues was analyzed by cell culture, then the above examinations were performed again after the aneurysm was embolized by micro coil (MC). Results All models were successfully established, and the MC embolization of aneurysm cavity achieved good efficacy. Vascular endothelial cells (VECs) proliferate well in vitro, and the VECs adhered to the sur?face of biodegradable polymeric materials successfully and grow into VEC layer structure. Hemodynamics analysis was per?formed in aneurysms model before and after embolization and relevant hemodynamic parameters was obtained. , Blood flow velocity are 2-7 cm/s in aneurysm and 8-26 cm/s in its parental artery. Conclusion A stable, ideal and handy intracranial aneurysm model was established and are essential in aneurysm related research.
