Relationship between effect of WEPO on tracheal smooth muscle andβand M receptors
10.7644/j.issn.1674-9960.2015.09.009
- VernacularTitle:马齿苋水提取物平喘作用与β受体和M受体的关系
- Author:
Guoyu WANG
;
Haoyu WANG
;
Lu WANG
- Publication Type:Journal Article
- Keywords:
Portulaca;
water extract;
anti-asthma;
βreceptor;
M receptor
- From:Military Medical Sciences
2015;(9):688-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-asthma mechanism of water extract of Portulaca oleracea L( WEPO) related toβand M receptors.Methods Rabbits of 2.0 -2.5 kg were selected,whose isolated tracheal rings were prepared.The effect of WEPO on tracheal smooth muscle tension was evaluated using tracheal smooth muscle contraction frequency and contraction amplitude as indexes.Aminophylline( Ami) was used as a positive control medicine and propranolol( Pro) as theβreceptor blocking agent to observe the relaxation effect on tracheal smooth muscle of WEPO related to βreceptors. Acetylcholine chloride( AChCl) was used as the agonist for M receptors and atronine( Atr) as the M receptor blocking agent to observe the relaxation effect on tracheal smooth muscle of WEPO related to M receptors.Results ①The contraction frequency and amplitude of isolated tracheal smooth muscle in each dose group of WEPO were significantly lower after treatment.The difference was statistically significant(P <0.05,P <0.01).②The baseline,contraction frequency and amplitude of isolated tracheal smooth in Pro +WEPO group were higher than in WEPO group and the difference was statistically significant (P<0.01).③The baseline, contraction frequency and amplitude of isolated tracheal smooth muscle in AChCl group were significantly higher after treatment(P<0.01)significantly.④The baseline, contraction frequency and amplitude in WEPO +AChCl group were not different from those in AChCl group ( P >0.05 ) .⑤These indexes in Atr+WEPO group were not different those in WEPO group ( P >0.05 ) .Conclusion WEPO has relaxation effect on isolated tracheal smooth muscle of rabbits,which is related toβreceptors rather than M receptors.
