Topological characteristics of postoperative survival rate-related molecules in hepatocellular carcinoma-associated complex networks
10.7644/j.issn.1674-9960.2015.09.010
- VernacularTitle:肝细胞癌术后生存率相关分子在复杂网络中的拓扑特性研究
- Author:
Guangyu SHAN
;
Yiming LU
;
Wubin QU
;
Chenggang ZHANG
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
surgical procedures,operative;
complex molecular network;
survival analysis;
gene expression;
miRNA
- From:Military Medical Sciences
2015;(9):691-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the network structure of genes and microRNA(miRNA) at the system level and to study topological characteristics of survival rate related molecules by means of survival analysis.Methods Regulatory networks were established with genes of hepatocellular carcinoma( HCC) and with the expression profiling data of miRNA. Survival knowledge in nodes was studied.Results All the nodes in gene co-expression networks conformed to power-law distribution.In a network, high-degree nodes were called Hub, which enriched more survival related genes than lower degree ones.Conclusion Hub nodes in gene regulatory networks promise to be potential features for molecular subtyping.
