Advances in double negative T cells in tumor immunotherapy
10.3760/cma.j.issn.1673-4203.2015.06.020
- VernacularTitle:双阴性T细胞在肿瘤免疫治疗中的研究进展
- Author:
Hong XU
;
Jiong CHEN
- Publication Type:Journal Article
- Keywords:
Immunity,cellular;
Pancreatic Neoplasms;
DNT cells;
NKG2D
- From:
International Journal of Surgery
2015;42(6):422-425
- CountryChina
- Language:Chinese
-
Abstract:
Double negative T cells,namely DNT cells,are specific regulatory cells with TCR+ CD3 + CD4-CD8-in cell phenotype,divide into αβ T cell and γδ T cell,play a very important role in regulating immunoreaction.Previous research restricted to the treatment of autoimmune disease and organ transplantation immunity.Recently dnt cells adoptive immunotherapy,as a new anti-tumor method,gradually come into public view.This review mainly focuses on the source of DNT cells,their anti-tumor effect,as well as the possible mechanism.
