Research progress of autophagy and its effect on acute pancreatitis
10.3760/cma.j.issn.1673-4203.2015.06.019
- VernacularTitle:自噬及其在急性胰腺炎中的研究进展
- Author:
Mingbing WU
;
Hao WU
;
Jianping GONG
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Autophagy;
Trypsinogen
- From:
International Journal of Surgery
2015;42(6):417-421
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis (AP) is activated trypsin-induced pancreatic and its peripheral tissue inflammation caused by their own digestion.The activation in advance of trypsinogen and the inflammation cascade in pancreatic acinar cells are thought to be a key mechanism of the onset and development of AP.Autophagy pathway acting as Ⅱ type of programmed cell death occurs in the early pathological course of AP,blockade of which contributes to aggravating necrosis of acinar cells in AP.This article mainly discussed the recent advances in the understanding of autophagy researches and its function in the mechanism of AP.
