Relationship Between Plasma Level of Asymmetric Dimethylarginine and Coronary Artery Ectasia in Relevant Patients
10.3969/j.issn.1000-3614.2015.09.03
- VernacularTitle:血浆非对称性二甲基精氨酸水平与冠状动脉扩张和狭窄的相关性
- Author:
Liang WANG
;
Shuyang ZHANG
;
Zhenyu LIU
;
Lianfeng CHEN
;
Hongyun WANG
- Publication Type:Journal Article
- Keywords:
Coronary artery ectasia;
Coronary artery disease;
Asymmetric dimethylarginine
- From:
Chinese Circulation Journal
2015;(9):833-836
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between plasma level of asymmetric dimethylarginine (ADMA) and coronary artery ectasia in relevant patients. Methods: A total of 72 patients received coronary angiography (CAG) in our hospital were studied and the patients were divided into 3 groups: Coronary ectasia group, Coronary stenosis group and Normal coronary group.n=24 in each group. Plasma levels of ADMA, symmetric dimethylarginine (SDMA) and L-arginine (Arg) were measured by HPLC-MS/MS methods. The relationship between ADMA and CAD was examined by Logistic regression analysis. Results: Plasma level of ADMA in Coronary ectasia group (0.437 ± 0.098) μmol/L and Coronary stenosis group (0.456 ± 0.088) μmol/L were higher than that in Normal coronary group (0.381 ± 0.057) μmol/L,P<0.05. The ratio of Arg/ADMA in Coronary ectasia group (208.54 ± 61.52) and Coronary stenosis group (220.00 ± 104.82) were lower than that in Normal coronary group (254.26 ± 76.22),P<0.05. Logistic regression analysis presented that with adjusted age, gender, smoking, family history of CAD and LDL-C level, and plasma ADMA was still related with CAD (Partial regression coefifcient 9.469, P=0.011). Conclusion: Plasma levels of ADMA were higher in patients with coronary artery ectasia/stenosis than those with normal coronary artery; while ADMA levels were similar between the patients with coronary ectasia and stenosis. Plasma ADMA level was the independent risk factor of CAD.
