Clinical Manifestation and Long-term Outcome in 566 Patients With Takayasu’s Arteritis
10.3969/j.issn.1000-3614.2015.09.07
- VernacularTitle:566例大动脉炎患者的临床特点及预后
- Author:
Lirui YANG
;
Huimin ZHANG
;
Xiongjing JIANG
;
Yubao ZOU
;
Fang QIN
;
Lei SONG
;
Ting GUAN
;
Haiying WU
;
Xianliang ZHOU
;
Jin BIAN
;
Rutai HUI
;
Deyu ZHENG
- Publication Type:Journal Article
- Keywords:
Takayasu’s arteritis;
Clinical manifestation;
Outcome
- From:
Chinese Circulation Journal
2015;(9):849-853
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore a single center large cohort of patients with Takayasu’s arteritis for their clinical manifestation and long-term outcome in China. Methods: We retrospectively analyzed 566 patients with Takayasu’s arteritis admitted in our hospital from 2002-01 to 2013-11 for their clinical characteristics, laboratory ifndings, angiographic features, treatment and long-term outcomes. Results: The patient’s ratio for female to male gender was 1 to 3.8 and the average onset age was (28.9 ± 12.0) years. The most common non-speciifc symptom, initial symptom and complication were fever (52/566 patients, 9.2%), dizziness (214 patients, 37.8%) and hypertension (392 patients, 69.3%) respectively. The patients with pulmonary artery and coronary artery involvement were 83 (14.7%) and 66 (11.7%) respectively, and 131 (23.1%) patients had faster erythrocyte sedimentation rate. The major vascular damage was steno-occlusive lesion and the most common involvement was left sub-clavian artery, which was observed in 278 (49.1%) patients. The treatments were mainly included in medication, interventional therapy, autologous blood vessel transplantation, artiifcial blood vessel transplantation and aortic valve replacement. There were 32 patients died during the mean follow-up period of (5.0 ± 0.2) years. Hypertension, complication and the progressive stage of disease were the major factors affecting prognosis in relevant patients (regression coefifcients: 4.664, 1.959 and 1.870 respectively, allP<0.05). Conclusion: Hypertension was the leading reason for patients’ hospital visit. Takayasu’s arteritis was closely related to cardiovascular disease, the early diagnosis and treatment were really important in clinical practice.
