Correlation between eosinophils and glucose and lipid metabolism disorder in obese children
10.3760/cma.j.issn.2095-428X.2015.19.009
- VernacularTitle:肥胖学龄儿童外周血嗜酸性粒细胞与糖脂代谢紊乱的关系
- Author:
Tingting LIU
;
Geli LIU
;
Juan HE
;
Xiaoming DING
;
Qingyan YANG
;
Rongxiu ZHENG
- Publication Type:Journal Article
- Keywords:
Obese;
Insulin resistance;
Lipids;
Blood glucose;
Eosinophils;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2015;(19):1473-1475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of eosinophils with glucose and lipid metabolism disorder in obese children. Methods A total of 180 subjects,102 boys and 78 girls,aged 7 to 14 years were enrolled in General Hospital,Tianjin Medical University. The subjects were divided into 3 quartiles according to eosinophil percentage. E1 (0 to<37% of eosinophils),E2(37% to<73% of eosinophils),and E3(73% to 100% of eosinophils). Forty-six chil-dren were selected as control group with matched age and sex (26 boys and 20 girls). The body weight,height,waist circumference,blood pressure,blood routine examination,fasting plasma glucose (FPG),fasting insulin (FINS),and blood lipid in 4 groups were measured. The values of glucose and lipid metabolism and the indexes of physical examina-tion were compared among each group. Results The values of eosinophil percentage,body mass index (BMI),trig-ly-ceride,total cholesterol, low-density lipoprotein cholesterol, FINS, FPG,homeostasis model assessment of insulin resistance(HOMA-IR) and waist circumference in E1,E2,E3 group were significantly higher than those in control group,and the value of high-density lipoprotein cholesterol was significantly lower than that in control group,and there were significant differences (all P<0. 05). The blood pressure was significantly higher in E1 groups than that in other 3 groups (all P<0. 05). The values of BMI and HOMA-IR in E1 group were higher than those of E3 group(all P<0. 05). Eosinophil percentage was positively correlated with FINS (r=0. 190,P=0. 01),and negatively correlated with BMI and HOMA-IR(r=-0. 259,-0. 190 respectively,all P<0. 05). Conclusions Obese children have emerged glucose and lipid metabolism disorders. Peripheral eosinophil percentage may be an early marker of insulin resistance.
