Recent advances of the etiology and mechanism of biliary atresia
10.3760/cma.j.issn.2095-428X.2015.19.021
- VernacularTitle:胆道闭锁病因及其发病机制研究进展
- Author:
Xiaoai CHEN
;
Jixin YANG
;
Jiexiong FENG
- Publication Type:Journal Article
- Keywords:
Biliary atresia;
Etiology;
Mechanism
- From:
Chinese Journal of Applied Clinical Pediatrics
2015;(19):1516-1518
- CountryChina
- Language:Chinese
-
Abstract:
Biliary atresia ( BA) is a pediatric liver disease characterized by progressive inflammation and fi-brosis of both the extrahepatic and intrahepatic bile ducts. Even though Kasai portoenterostomy increases the survival of children with BA, 80% of patients with BA will eventually require liver transplantation, making this condition the leading indication for pediatric liver transplantation worldwide. Currently,the causes of this disease are largely unde-fined and theories of pathogenesis include viral infection,autoimmune-mediated bile duct destruction,and abnormalities in bile duct development.
