Therapy for disseminated intravascular coagulation
10.3760/cma.j.issn.2095-428X.2015.18.003
- VernacularTitle:弥散性血管内凝血的治疗
- Author:
Feiqiu WEN
;
Huirong MAI
- Publication Type:Journal Article
- Keywords:
Disseminated intravascular coagulation;
Therapy;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2015;(18):1368-1371
- CountryChina
- Language:Chinese
-
Abstract:
Disseminated intravascular coagulation ( DIC ) is a exceedingly complicated pathophysiological process,both pro and anti coagulation factors are activated and consumed,it is difficult to determine acute stage of the syndrome for physicians based on clinical presentations and laboratory tests,management strategy of DIC is not same due to different etiology,the dose and regimen of drug administration are uncertain. At present pediatricians usually treat children patients with DIC according to researches and guidelines for adults. The key strategies to DIC management is to treat underlying diseases aggressively so as to clear risk factors triggering extensive coagulation and resuscitate with ap-propriate blood products. No clinical trials have proved that heparin can improve clinical outcome,efficacies of activated protein C,antithrombin, tissue factor pathway inhibitor and thrombomodulin are needed to be verified by more high qua-lity clinical trials in DIC treatment.
