The detection value of (1,3)-β-D-glucan in clinical deep fungal infection
10.3760/cma.j.issn.1008-6706.2015.19.019
- VernacularTitle:（1，3）-β-D葡聚糖检测在深部真菌感染中的应用价值
- Author:
Yuehong JIANG
;
Lifang SUN
;
Enhang FENG
- Publication Type:Journal Article
- Keywords:
Dextran;
Fungal infections;
Laboratory diagnosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(19):2941-2943
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the detection value of(1,3)-β-D -glucan in the early diagnosis of fun-gal infection in clinic.Methods 86 patients with deep fungal infection were selected as the study group,and 24 cases of healthy volunteers were selected as the control group,all groups took plasma G test,while cultivating specimens sus-pected infection and deep fungal infections in patients were divided according to culture -negative group and positive group,plasma G test results were compared.Results In the control group,G test was (6.12 ±2.87)×10 -3 ng/mL in plasma,deep fungal infection negative,positive test results were (32.58 ±24.12)×10 -3 ng/mL and (101.28 ± 36.04)×10 -3 ng/mL in plasma G respectively,positive group G results in plasma were significantly increased,the differences were statistically significant(t =18.28,7.92,P =0.036,0.042);both positive plasma G test results were significantly higher than that of the negative group,the difference was statistically significant(t =12.16,P =0.038). Plasma G test positive diagnosis of deep fungal infection was 79.1%,significantly better than the fungal culture 50.0%,the difference was statistically significant(χ2 =31.26,P =0.002).Conclusion In early clinical diagnosis of deep true infection,plasma G test positive rate is higher than fungal culture,and is worthy of wider application.
