Research progress of bone marrow mesenchymal stem cells in the treatment of retinopathy

VernacularTitle:骨髓间充质干细胞在视网膜病变治疗中的研究进展
Author: Qianqian MA ; Zhichun FENG
Publication Type:Journal Article
Keywords: Bone marrow mesenchymal stem cell; Biological characteristics; Retinopathy
From: Chinese Journal of Applied Clinical Pediatrics 2015;(18):1431-1433
CountryChina
Language:Chinese
Abstract: Stem cell therapy for retinal disease is under way,and several clinical trials are currently recruiting. These trials use human umbilical cord tissue-derived stem cells and bone marrow-derived stem cells to treat visual dis-orders such as age-related macular degeneration,and retinitis pigmentosa. Mesenchymal stem cells( bone marrow mes-enchymal stem cells,BMSCs) belong to adult pluripotent stem cells,capable of unlimited self-renewal,have the poten-tial multi-directional differentiation,and more recent researches,mainly through such cells can differentiation into reti-nal characteristics and morphology similar to or the same structural characteristics of functional impairment, which is widely used in the treatment of retinal diseases. In recent years′researches,whether in the vivo or in vitro experiments, BMSCs have the potential to differentiate into nerve cells offering the selectivity of treatment in retinal injury and disea-ses. So,this view discussed the biological characteristics of BMSCs and bone marrow in the mechanism of action of reti-nopathy,relevant treatment.