Autophagy and acute kidney injury
10.3760/cma.j.issn.2095-428X.2015.18.020
- VernacularTitle:自噬与急性肾损伤
- Author:
Fenglan LUO
;
Yamei WANG
;
Yuhong TAO
- Publication Type:Journal Article
- Keywords:
Cell autophagy;
Autophosome;
Acute kidney injury
- From:
Chinese Journal of Applied Clinical Pediatrics
2015;(18):1434-1436
- CountryChina
- Language:Chinese
-
Abstract:
Not only does autophagy play a vital role in maintaining kidney cell survival and homeostasis,but al-so it is involved in the pathophysiology of several kidney diseases. Recent studies have indicated that autophagy was ac-tivated in kidney cells during acute kidney injury and its regulatory mechanism was unclear. Autophagy activation in kidney may be associated with oxidative stress, endoplasmic reticulum stress, hypoxia inducible factor-1α, p53 and Bcl-2 family. The role of autophagy in acute kidney injury is still controversial. Most believe that it plays a protective role during acute kidney injury. Therefore autophagy will become a novel and potential target for the prevention and treatment of acute kidney injury.
