Effect of Electroacupuncture on Motilin and Somatostatin inRats with Diabetes Gastroparesis
10.13460/j.issn.1005-0957.2015.09.0892
- VernacularTitle:电针对糖尿病胃轻瘫大鼠胃动素及生长抑素的影响
- Author:
Xiuhong LI
;
Guohua LIN
;
Zhuocheng ZOU
- Publication Type:Journal Article
- Keywords:
Acupuncture therapy;
Electrocupuncture;
Diabetic complications;
Gastroparalysis syndrome;
Motilin;
Somatostatin;
Rats
- From:
Shanghai Journal of Acupuncture and Moxibustion
2015;(9):892-895
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of electroacupuncture on motilin (MOT) and somatostatin (SS) in rats with diabetes gastroparesis (DGP). Methods One hundred clean healthy SD rats with negative urine glucose were chosen. After they were fed for three days and into a stable state, 30 rats were randomly selected as a control group. The other 70 rats were used as an animal model of insulin-dependent diabetes made with streptozotocin. At 10 weeks after model making, rats as successful models were randomly allocated to model and treatment groups, 30 rats each. The model group received no treatment and the treatment group, electroacupuncture at points Zusanli, Zhongwan and Weishu. Serum and antral MOT and SS were measured in every group before and after treatment. Results There were statistically significant differences in body weight and gastrointestinal propulsion rate between the treatment or model group of rats and the control group (P<0.01), and between the treatment and model groups after treatment (P<0.01). There was a statistically significant difference in blood glucose value between the treatment or model group of rats and the control group after model making and at 10 weeks and the end of treatment (P<0.01). There was a statistically significant difference in blood glucose value between at the end and 10 weeks of treatment in the treatment group (P<0.01). There were statistically significant differences in serum and antral MOT and SS contents between the treatment or model group and the control group (P<0.01), and between the treatment and model groups after treatment (P<0.01). Conclusions Electrocupuncture can markedly increase serum SS and antral MOT and decrease serum MOT and antral SS to ameliorate high blood motilin and somatostatin in DGP rats.
