A Case of Cytomgalovirus Infection Presenting as Nodule and Ulcer in an Immunocompromised Patient.
- Author:
Gee Young BAE
1
;
Deuk Pyo LEE
;
Sung Eun CHANG
;
Mi Woo LEE
;
Kee Chan MOON
;
Jai Kyoung KOH
Author Information
1. Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. derm@www.amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Cytomegalovirus;
Infection in immuncompromised patients
- MeSH:
Acantholysis;
Biopsy;
Cicatrix;
Cyclosporine;
Cytomegalovirus;
Dermis;
Endothelial Cells;
Epidermis;
Fibroblasts;
Ganciclovir;
Giant Cells;
Humans;
Immunocompromised Host*;
Kidney Transplantation;
Male;
Middle Aged;
Neutrophils;
Penis;
Prednisolone;
Scrotum;
Ulcer*;
Vasculitis;
Viremia
- From:Korean Journal of Dermatology
2003;41(2):214-218
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report the case of a 48-year-old man presenting with a pubic nodule and multiple ulcers on penis and scrotum. He had a kidney transplantation two months ago and has been taking cyclosporine, prednisolone, and mycophenolate mofetil. The biopsy specimen from the nodule showed vasculitis and multiple cytomegalic cells in dermis. The biopsy specimen from the scrotal ulcer showed a cluster of multinucleated giant cells and acantholysis in epidermis and cytomegalic cells and vasculitis in dermis, suggestive of HSV infection in epidermis and CMV infection in dermis. Specific immunoperoxidase for CMV antigens positively stained cytomegalic endothelial cells and fibroblasts in both specimens. Evidence of CMV viremia as pp65 was detected in circulating polymorphonuclear leukocytes by immunocytochemical tests although there was no evidence of other organ involvement. Immediately, he was placed on intravenous ganciclovir therapy for 3 weeks. The lesions cleared leaving scars and he was discharged in good general condition.
