Rodent Models of Schizophrenia and their behavioral evaluation
10.3969/j.issn.1671.7856.2015.009.014
- VernacularTitle:精神分裂症啮齿类动物模型及其行为学检测
- Author:
Xi CHEN
;
Hongshun GU
;
Lin LI
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Model,animal;
Behavior;
Positive symptoms;
Negative symptoms;
Cognitive impairment;
Rodents
- From:
Chinese Journal of Comparative Medicine
2015;(9):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Schizophreniaisacommonandseriousmentaldisorder,whichcausesgreatharmtopatientsandtheir families.Because of the complicated pathogenesis of schizophrenia , there are still many problems in its drug treatment . Stable and reliable animal models are required for preclinical studies of new drugs .In this article , we reviewed the rodent models associated with positive symptoms , negative symptoms and cognitive impairment of schizophrenia and the behavioral evaluation on these models , hoping to provide useful references of animal models for the antipsychotic drug screening and preclinical studies .
