The level of serum heme oxygenase-1 and carbon monoxide in children with mycoplasma pneumoniae infection
10.3760/cma.j.issn.1673-4912.2015.09.004
- VernacularTitle:肺炎支原体感染患儿血血红素加氧酶-1与一氧化碳含量变化及其临床意义
- Author:
Xianyao LIN
;
Yi WEI
;
Ting XU
;
Jielin ZHOU
;
Dong CHEN
;
Kai WANG
- Publication Type:Journal Article
- Keywords:
Heme oxygenase-1;
Carbon monoxide;
Mycoplasma pneumoniae
- From:
Chinese Pediatric Emergency Medicine
2015;22(9):607-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of heme oxygenase-1 ( HO-1 ) and carbon monoxide ( CO) in children with mycoplasma pneumoniae infection. Methods A total of 198 cases with mycoplasma pneumoniae infection under 3 years were enrolled in this study. According to whether with wheezing,all cases were divided into wheezing group( n=58 ) and no wheezing group ( n=140 ) . According to having hypox-emia,wheezing group was divided into mild wheezing group(n=34) and severe wheezing group(n=24). And no wheezing group was set as control group. The serum COHb levels were measured by dual-wavelength spectrophotometry. The serum HO-1 were measured by ELISA. Results The levels of serum HO-1 and COHb% in severe wheezing group were ( 2 734. 10 ± 707. 59 ) ng/L, ( 3. 88 ± 0. 83 )%, and ( 1 130. 03 ± 671. 02) ng/L,(1. 16 ± 0. 63)% in mild wheezing group,and(931. 32 ± 451. 67) ng/L,(1. 04 ± 0. 37)% in no wheezing group,respectively. There were significant differences in serum HO-1 and COHb% between se-vere wheezing group and mild wheezing group(P<0. 01,respectively),and there were no significan differ-ences in serum HO-1 and COHb% between mild wheezing group and no wheezing group( P>0. 05,respec-tively). There was significant positive correlation between serum HO-1 and COHb%(r=0. 875,P<0. 01). Conclusion With mycoplasma pneumoniae infection,the expression of HO-1 and COHb% increase by the wheezing disease progression. HO-1 and CO may participate in the development process of infantile wheezing diseases.
