Evaluation of outcome and cerebral protective effects for ketogenic diet therapy to status epilepticus
10.3760/cma.j.issn.1673-4912.2015.09.006
- VernacularTitle:生酮饮食对癫痫持续状态的疗效及脑保护作用研究
- Author:
Jialun WEN
;
Jianxiang LIAO
;
Xianling MENG
;
Sufang LIN
;
Tieshuan HUANG
;
Jinghua YE
- Publication Type:Journal Article
- Keywords:
Status epilepticus;
Neuron specific enolase;
S100β;
Ketogenic diet
- From:
Chinese Pediatric Emergency Medicine
2015;22(9):614-616
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of ketogenic diet( KD) in the treatment of status epi-lepticus( SE) and whether KD could protect the brain,and propose a new thought on SE patients′reasonably individualized treatment, brain protection and prognosis improvement. Methods From Sep 2013 to Jan 2015,all the patients diagnosed as SE were advised to apply KD treatment; the patients who refused KD treatment were included in the control group,while the patients who accepted KD treatment were included in the treatment group. Based on the SE treatment principles,the control group applied traditional anti-convulsive therapy,while the treatment group applied traditional therapy combined with KD treatment. Before the treat-ment and after the epilepsy control,the patients′ serum was collected to test neuron specific enolase( NSE) and S100βlevels,and the duration of epilepsy control was recorded. Results The treatment group included a total of 10 patients; 3 patients had a good efficacy and obtained seizure-free after the treatment; clinical seizures declined significantly in 6 patients. The treatment group′s overall response rate was 9/10,which was higher than that of the control group(5/8)(P<0. 01). The treatment group′s duration to gain efficacy was shorter than that of the control group[(5. 2 ± 2. 9) d vs. (9. 8 ± 1. 5) d,P<0. 01]. After the treatment,the patients′NSE and S100β in both groups were significantly decreased than those before the treatment ( P<0. 001 or P<0. 05). After the treatment,the serum NSE and S100β of the patients in the treatment group were lower than those in the control group,with statistically significant difference(P<0. 05). Conclusion Frequent epileptic seizures and SE would impair the patient′s brain. Controlling the epileptic seizures actively could lower the severity of brain injury. KD could effectively control the epileptic seizure and had neuropro-tective effects.
