Recent advances in research of cofactor C1q related diseases
10.3760/cma.j.issn.1009-9158.2015.09.017
- VernacularTitle:补体C1q与疾病发生发展相关性研究的新进展
- Author:
Menglei DING
;
Lieying FAN
- Publication Type:Journal Article
- Keywords:
Complement C1q;
Kidney diseases;
Graft rejection;
Atherosclerosis;
Aging
- From:
Chinese Journal of Laboratory Medicine
2015;(9):642-645
- CountryChina
- Language:Chinese
-
Abstract:
The complement cascade, as a part of innate immune system, plays a major role in phagocytosis, clearance of apoptotic cells, immune response and inflammation.As an initiator of the classical pathway, C1q not only facilitates apoptotic debris removal but also gets involved in the maintenance of vascular endothelial integrity.As a result, deficiency, excessive consumption or dysfunction of C1q leads to the imbalance of such mechanisms and increases the susceptibility of nephropathy, atherosclerosis and central nervous system diseases.Recenlty, C1q was identified as a new biomarker of aging.C1q could be a useful indicator for early diagnosis, therapy and prognosis.
