Effect of Acupuncture on Serum TNF-?and IL-6 Contents in Cerebral Hemorrhage Rats

VernacularTitle:针刺对脑出血大鼠血清TNF-?、IL-6含量的影响
Author: Qiuxin CHEN ; Wei ZOU ; Mingming NIU ; Peng LIU ; Dong YAO ; Yu BAO ; Xiaowei SUN
Publication Type:Journal Article
Keywords: Acupuncture; Tumor necrosis factor; Interleukin-6; Cerebral hemorrhage; Rats
From: Shanghai Journal of Acupuncture and Moxibustion 2015;(10):1006-1008
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the effect of acupuncture on motor function and serum expressions of TNF-aand IL-6 contents in cerebral hemorrhage rats.MethodSeventy-two male Wistar rats were randomized into sham operation, model and acupuncture groups. A rat model of cerebral hemorrhage was made by intracerebral injection of autoblood. Baihui-to-Qubin acupuncture was performed after successful model making. The TNF-aand IL-6 contents of rat serum were measured by enzyme linked immunosorbent assay at three time points: one, three and seven days.ResultBaihui-to-Qubin acupuncture markedly increased the neurological function score and reduced neurologic deficits in cerebral hemorrhage rats. At the same time point, serum TNF-aand IL-6 contents were significantly lower in the acupuncture group of rats thanin the model and acupuncture group; there were statistically significant differences (P<0.01).ConclusionBaihui-to-Qubin acupuncture can reduce neurologic deficits in cerebral hemorrhage rats. It may be related to decreases in serum TNF-aand IL-6 contents after acupuncture.