Abnormal expression and clinical significance of miR-146a in the peripheral blood mononuclear cells of patients with type 2 diabetic peripheral neuropathy

VernacularTitle:miR-146 a在2型糖尿病周围神经病变患者外周血单个核细胞中的异常表达及临床意义
Author: Guofeng WANG ; Ning XU ; Tao YANG
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; miR-146a; Diabetic peripheral neuropathy
From: Chinese Journal of Endocrinology and Metabolism 2015;(9):748-751
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression levels of miR-146a in the peripheral blood mononuclear cells ( PBMCs ) of patients with diabetic peripheral neuropathy ( DPN ) and their correlation with the disease severity. Methods The expression levels of miR-146a in the PBMCs were measured by using real time PCR in 62 patients with type 2 diabetes (32 patients without DPN, 30 with DPN) and 33 healthy individuals. The correlation of miR-146a expression with clinical parameters was analyzed. Results The expression level of miR-146a in patients withtype2diabetesmellituswassignificantlylowerthanthatinthehealthyindividuals((1.92±1.99vs4.15±1.56, P<0. 05). Furthermore, the miR-146a level was significantly lowered in diabetic patients with DPN as compared with thosewithoutDPN(1.22±1.61vs2.51±2.00,P<0.05). TheexpressionlevelsofmiR-146ainpatientswithDPN were positively correlated with duration of diabetes, blood glucose, and Toronto clinical scoring system scores. Conclusion The decreased expression of miR-146a in patients with DPN is correlated with the severity of DPN.