A meta-analysis of stroke risk in type 2 diabetic patients treated with sulfonylurea

VernacularTitle:2型糖尿病患者应用磺脲类药物与脑中风风险性的meta分析
Author: Rui LIU ; Baofeng XU ; Lingli ZHOU ; Bo LIU
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Stroke; Sulfonylureas; Meta analysis
From: Chinese Journal of Endocrinology and Metabolism 2015;(9):758-764
CountryChina
Language:Chinese
Abstract: Objective To investigate whether sulfonylurea ( SU) increases the risk of stroke in patients with type 2 diabetes mellitus(T2DM). Methods A systemic meta-analysis including 17 random control trails(RCT) was performed to compare the risk of stroke between type 2 diabetic patients treated with SUs and comparators. Results 1 612 articles were retrieved, and finally 17 articles were included. Patients receiving SUs treatment had a higher relative risk of stroke (RR 1. 35, 95% CI 1. 13-1. 60) than those who received comparators. The I2 statistic for heterogeneity between 17 trails was 0. 0%(P=0. 687). No major asymmetry appeared in the funnel plot and Begg′adjusted rank correlation test(kendall′s score=22, P=0. 387). Conclusion The use of SUs may raise the risk of stroke which is already high in patients with T2DM.