Association of the rs6832151 within chromosomal band 4p14 with Graves′disease
10.3760/cma.j.issn.1000-6699.2015.09.011
- VernacularTitle:4 p14区段rs6832151多态性与Graves病相关性研究
- Author:
Wendi ZHAO
;
Weihua SUN
;
Shuangxia ZHAO
;
Huaidong SONG
;
Xiaomei ZHANG
- Publication Type:Journal Article
- Keywords:
Graves′disease;
4p14;
Rs6832151;
Polymorphism,Single nueleotide
- From:
Chinese Journal of Endocrinology and Metabolism
2015;(9):787-790
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] The genotypes of rs6832151 in the 4p14 were genotyped by Taqman probe technique on FluidigmEPl platform in 617 patients with Graves′disease( GD) and 4 915 health control subjects. The result showed thatRs6832151 Gin4p14wasstronglyassociatedwithGD(OR=1.39,P<0.01),withstatisticalsignificancefor three genetic models according to the locus genotyping ( additive model,dominant model,and recessive model,all P<0.01). There was no statistically significant difference in the sizes of goiter between the genotype subgroups(P>0. 05). The result suggests that rs6832151 G in 4p14 is the susceptibility genes of Graves′ disease in Bengbu population, and is related to the high risk of GD.
