Progress in carriers of anticancer paclitaxel
- VernacularTitle:抗肿瘤药紫杉醇载体的研究进展
- Author:
Zhenlei YANG
;
Sixi ZHANG
;
Guihua HUANG
- Publication Type:Journal Article
- Keywords:
paclitaxel;
liposomes;
micelles;
microspheres;
nanoparticles;
progress
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(9):183-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the progress of paclitaxel carriers, to provide theoretical support for research of paclitaxel carriers and clinical use of paclitaxel.Methods To study literatures on paclitaxel carriers recently and understand the research direction of paclitaxel carriers.Subsequently, the advantages and disadvantages of various paclitaxel carriers were analyzed and summarized.Results Paclitaxel as an effective anti-tumor chemotherapy drugs, had poorly water-soluble, serious toxicity and side effects, which limited the wide application of paclitaxel to some degree.Development of liposomes, micelles, microspheres, nanoparticles and other new dosage forms had broken these restrictions, which had vital significance.Conclusion Paclitaxel carriers can improve the solubility of the drug, reduce side effects, and develop toward multi-functional and finely targeted.
